Obesity has a multifaceted effect on reproductive health in men. It was found that in patients with high body mass index and waist circumference a reduced volume of the seminal fluid, which is released during ejaculation, as well as oligozoospermia. The latter condition is characterized by a reduced number and concentration of the spermatozoa in the composition of the seminal fluid. Increased accumulation of adipose tissue is associated with abnormalities in sperm morphology. Changes in the function of male germ cells are also observed, which disrupts the development of the embryo after fertilization of the egg and lowers the chances of successful fertilization.
Obesity in men is associated with reduced serum concentrations of testosteronehigh values of estradiol – the female sex hormone, impaired process of spermatogenesis and erectile dysfunction. The latter condition is due to the atherogenic effects that are observed on the peripheral vessels. In addition, an increase in temperature in obesity is also characteristic the testicles and decreased level of the mediators of the inflammation.
Under physiological conditions, spermatogenesis is controlled by the action of follicle stimulating FSH and luteinizing hormone – LH on the testicles. These hormones, in turn, are released as a result of the stimulating action of gonadotropin-releasing hormone, which is produced and secreted by the hypothalamus. In obese patients, decreased serum concentrations of testosterone and the globulin that binds sex hormones – SHBG. It is seen more often in affected patients infertility due to the increase in temperature in the testicles, which is the result of sedentary lifestyle. This leads to an increase in the levels of female sex hormones – estrogens and disruption of hypothalamic-pituitary-gonadal axis function.
Adipose tissue produces adipokines that can lead to severe forms of inflammation and oxidative stress in the male reproductive organs. These consequences lead to tissue damage in the testicles and epididymis. In patients with obesity decreased quality is observed the spermatozoa. Their motility is impaired, as well as damage to the genetic material, the acrosome reaction and the concentration of spermatozoa in the composition of the seminal fluid. Visceral adipose tissue leads to changes in hormonal balance, which causes chronic inflammation in the genitals and an increase in temperature in the scrotum, due to the accumulation of fatty tissue in this area. All this impairs sperm quality and increases the risk of infertility in men.
The material is informative and cannot replace consultation with a doctor. Before starting treatment, you must consult a doctor.